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The Psychoactive Promise


Psychoactive Press is not affiliated with any organization, and strives wholly to move the conversation forward with captivating, well-cited and original interdisciplinary discourse on the subject of psychedelic experience. We invest a great deal of time and care in preserving the fidelity and integrity of the information we present. If you feel this work does not live up to those standards, or would like to contact us for any reason, please reach out to hello@psychoactive.ca.


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About the author


Eric M. Fortier holds an Honours Bachelor of Arts in psychology from the University of Ottawa, Canada. He has been actively studying psychedelic literature, sharing correspondence with its authors, and engaging in discourse with the community for several years. His work primarily centers on how psychedelic experience can lead to insight and changes in priorities and behaviour and help us better allocate our resources. With Pychoactive Press, he aims to help us better and more safely think about, communicate, and use altered states of consciousness. He is the author of the book Psychedelotropism and of articles such as β€˜Can You Feel It? On Psychedelic Microdosing,’ and β€˜D.W. Woolley, the Serotonin Hypothesis, and the Genesis of Psychopharmacology.’

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References for Psychedelotropism:


Azmitia, E. C. (2007). Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis. International Review of Neurobiology, 77, 31–56. https://doi.org/10.1016/S0074-7742(06)77002-7

Lee, J.-H., Wood, T. K., & Lee, J. (2015). Roles of Indole as an Interspecies and Interkingdom Signaling Molecule. Trends in Microbiology, 23(11), 707–718. https://doi.org/10.1016/j.tim.2015.08.001

Azmitia, E. C. (2010). CHAPTER 1.1 - Evolution of Serotonin: Sunlight to Suicide. Handbook of Behavioral Neuroscience, 21, 3–22. https://doi.org/10.1016/S1569-7339(10)70069-2

Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015). Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response. Neuroscience and biobehavioral reviews, 51, 164–88. https://doi.org/10.1016/j.neubiorev.2015.01.018

Patrick, R. P., & Ames, B. N. (2015). Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2207–2222. https://doi.org/10.1096/fj.14-268342

Fraikin, G. {. Ya}., Strakhovskaya, M. G., Ivanova, E. V., & Rubin, A. B. (1989). Near-UV activation of enzymatic conversion of 5-hydroxytryptophan to serotonin. Photochemistry and Photobiology, 49(4), 475–477. https://doi.org/10.1111/j.1751-1097.1989.tb09197.x

Lesch, K.-P., & Waider, J. (2012). Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron, 76(1), 175–191. https://doi.org/10.1016/j.neuron.2012.09.013

Meneses, A. & Liy-Salmeron, G. (2012). Serotonin and emotion, learning and memory. Reviews in the Neurosciences, 23(5-6), 543-553. https://doi.org/10.1515/revneuro-2012-0060

Behrens, T. E. J., Hunt, L. T., Woolrich, M. W., & Rushworth, M. F. S. (2008). Associative learning of social value. Nature, 456(7219), 245. https://doi.org/10.1038/nature07538

Gu, Q. (2007). Serotonin Involvement in Plasticity of the Visual Cortex. In: Tseng KY., Atzori M. (Eds.) Monoaminergic Modulation of Cortical Excitability. Boston, MA: Springer.

Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264–355. https://doi.org/10.1124/pr.115.011478

Driscoll, M. E., & Tadi, P. (2020). Neuroanatomy, Inferior Colliculus. StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK554468

Nakamura, K. (2013). The role of the dorsal raphΓ© nucleus in reward-seeking behavior. Frontiers in Integrative Neuroscience, 7. https://doi.org/10.3389/fnint.2013.00060

Giovanni, G. D., Matteo, V. D., Espositio, E. (Eds). Serotonin-Dopamine Interaction – Experimental, Clinical and Therapeutic Evidence. Progress in Brain Research, 172, 1-665. Elsevier Science.

Marsden, C. A. (2010). CHAPTER 1.7 - Measuring Serotonin Activity in vivo in the Brains of Animals and Humans. In MΓΌller, C. and Jacobs, B. (Eds), Handbook of the Behavioral Neurobiology of Serotonin. Handbook of Behavioral Neuroscience, 21, 139–149. https://doi.org/10.1016/S1569-7339(10)70075-8

Donovan, M. H., & Tecott, L. H. (2013). Serotonin and the regulation of mammalian energy balance. Frontiers in neuroscience, 7, 36. https://doi.org/10.3389/fnins.2013.00036

Jacobs, B.L. & Fornal, C.A. (2010) Activity of brain serotonergic neurons in relation to physiology and behavior. In: Muller, C. & Jacobs, B. (Eds.) Handbook of Behavioral Neurobiology of Serotonin. NY: Elsevier Academic Press. pp 153-162

Palmer, J. A., & Palmer, L. K. (2002). Chapter 7: Social Order and Disorder - The Biochemistry of Status and the Function of Mood States. In Evolutionary psychology: The ultimate origins of human behavior (p. 173). Boston, MA: Allyn and Bacon.

Kravitz, E. A. (2000). Serotonin and aggression: insights gained from a lobster model system and speculations on the role of amine neurons in a complex behavior. Journal of Comparative Physiology A, 186(3), 221–238. https://doi.org/10.1007/s003590050423

Wu, J., Kramer, G. L., Kram, M., Steciuk, M., Crawford, I. L., & Petty, F. (1999). Serotonin and learned helplessness: a regional study of 5-HT1A, 5-HT2A receptors and the serotonin transport site in rat brain. Journal of Psychiatric Research, 33(1), 17–22. https://doi.org/10.1016/S0022-3956(98)00041-7

Ziomkiewicz-Wichary A. (2016). Serotonin and Dominance. In: Weekes-Shackelford V., Shackelford T., Weekes-Shackelford V. (eds) Encyclopedia of Evolutionary Psychological Science. Springer, Cham. https://doi.org/10.1007/978-3-319-16999-6

Young, S. N. and Leyton, M. (2002). The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol. Biochem. Behav., 71: 857-865

Azmitia, E. C. (2010). CHAPTER 1.1 - Evolution of Serotonin: Sunlight to Suicide. Handbook of Behavioral Neuroscience, 21, 3–22. https://doi.org/10.1016/S1569-7339(10)70069-2

Alex Belser: The Psychedelic Mystical Experience. (2018, October 26). Youtube. Retrieved from https://www.youtube.com/watch?v=BE80piBCdNs&t=926

Belser, A. B., Agin-Liebes, G., Swift, T. C., Terrana, S., Devenot, N., Friedman, H. L., ...Ross, S. (2017). Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological Analysis. Journal of Humanistic Psychology, 57(4), 354–388. https://doi.org/10.1177/0022167817706884

Kraehenmann, R., Pokorny, D., Vollenweider, L., Preller, K. H., Pokorny, T., Seifritz, E., & Vollenweider, F. X. (2017a). Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation. Psychopharmacology, 234(13), 2031–2046. https://doi.org/10.1007/s00213-017-4610-0

Leung, L. C., Wang, G. X., Madelaine, R., Skariah, G., Kawakami, K., Deisseroth, K., … Mourrain, P. (2019). Neural signatures of sleep in zebrafish. Nature, 571(7764), 198–204. https://doi.org/10.1038/s41586-019-1336-7

Cipolli, C., Bolzani, R., Tuozzi, G., & Fagioli, I. (2001). Active processing of declarative knowledge during REM-sleep dreaming. Journal of Sleep Research, 10(4), 277–284. https://doi.org/10.1046/j.1365-2869.2001.00268.x

Hall, C. S., & Van De Castle, R. L. (1966). The content analysis of dreams. New York: Appleton-Century-Crofts.

Masters, R., Houston, J. (1996/2000). The Varieties of Psychedelic Experience. Rochester, NY: Inner Traditions Bear and Company.

Shanon, B. (2002). Antipodes of the mind: charting the phenomenology of the Ayahuasca experience. Oxford: Oxford University Press.

Feindberg, B. (2018). Undiscovering the Pueblo MΓ‘gico: Lessons from Huautla for the Psychedelic Renaissance. In: Labate, B. C. & Cavnar, C. (Eds.) Plant Medicines, Healing and Psychedelic Science: Cultural Perspectives. Springer. Springer International Publishing. https://doi.org/10.1007/978-3-319-76720-8

MacDonald, G., & Leary, M. R. (2005). Why Does Social Exclusion Hurt? The Relationship Between Social and Physical Pain. Psychological Bulletin, 131(2), 202-223. https:// doi.org/10.1037/0033-2909.131.2.202

Cacioppo, J. T., Cacioppo, S., Capitanio, J. P., & Cole, S. W. (2015). The neuroendocrinology of social isolation. Annual review of psychology, 66, 733–67. https://doi.org/10.1146/annurev-psych-010814-015240

Xia, N., & Li, H. (2018). Loneliness, Social Isolation, and Cardio-vascular Health. Antioxidants & Redox Signaling, 28(9), 837. https://doi.org/10.1089/ars.2017.7312

Helm, P. J., Lifshin, U., Chau, R., & Greenberg, J. (2019). Existential isolation and death thought accessibility. Journal of Research in Personality, 82, 103845. https://doi.org/10.1016/j.jrp.2019.103845

Preller, K. H., Pokorny, T., Hock, A., Kraehenmann, R., StΓ€mpfli, P., Seifritz, E., ...Vollenweider, F. X. (2016). Effects of serotonin 2A/1A receptor stimulation on social exclusion processing. Proceedings of the National Academy of Sciences, 113(18), 5119–5124. https://doi.org/10.1073/pnas.1524187113

Argento, E., Strathdee, S. A., Tupper, K., Braschel, M., Wood, E., & Shannon, K. (2017). Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting. BMJ Open, 7(9), e016025. https://doi.org/10.1136/bmjopen-2017-016025

Schmid, Y., Enzler, F., Gasser, P., Grouzmann, E., Preller, K. H., Vollenweider, F. X., ...Liechti, M. E. (2015). Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects. Biological Psychiatry, 78(8), 544–553. https://doi.org/10.1016/j.biopsych.2014.11.015

Schmidt, A., Kometer, M., Bachmann, R., Seifritz, E., & Vollenweider, F. (2013). The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions. Psychopharmacology, 225(1), 227–239. https://doi.org/10.1007/s00213-012-2811-0

Griffiths, R. R., Johnson, M. W., Richards, W. A., Richards, B. D., Jesse, R., MacLean, K. A., ...Klinedinst, M. A. (2017). Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors. Journal of Psychopharmacology, 32(1), 49–69. https://doi.org/10.1177/0269881117731279

Evans, L. T., Abramson, H. A., & Abramson, H. A. (1958). Lysergic Acid Diethylamide (LSD-25): XXVI. Effect on Social Order of the Fighting Fish, Betta Splendens. Journal of Psychology, 45(2), 263–273. https://doi.org/ 10.1080/00223980.1958.9916257

Barrett, D. (2017). Dreams and creative problem-solving. Annals of the New York Academy of Sciences, 1406(1), 64–67. https://doi.org/10.1111/nyas.13412

Kaempfert, W. B. (1924). A popular history of American invention. New York: C. Scribner’s Sons.

Valenstein, E. S. (2012). The War of the Soups and the Sparks - The Discovery of Neurotransmitters and the Dispute Over How Nerves Communicate. New York: Columbia University Press.

Ranganathan, S. R. (1967). Ramanujan, the man and the mathematician. Bombay: Asia Pub. House.

Baggott, M. J. (2015). Psychedelics and creativity: a review of the quantitative literature. PeerJ PrePrints 3:e1202v1. https://doi.org/10.7287/peerj.preprints.1202v1

World Science Festival. (2019, Aug 16). Revealing the Mind: The Promise of Psychedelics [Video file]. Retrieved from https://www.youtube.com/watch?v=Fi66wFfOC-4

Markoff, J. (2005). What the Dormouse Said - How the Sixties Counterculture Shaped the Personal Computer Industry. Viking Press.

Pokorny, T., Duerler, P., Seifritz, E., Vollenweider, F. X., & Preller, K. H. (2019). LSD acutely impairs working memory, executive functions, and cognitive flexibility, but not risk-based decision-making. Psychological Medicine, 1–10. https://doi.org/10.1017/s0033291719002393

Family, N., Vinson, D., Vigliocco, G., Kaelen, M., Bolstridge, M., Nutt, D. J., et al. (2016). Semantic activation in LSD: evidence from picture naming. Language, Cognition and Neuroscience, 31, 1320–1327. https://doi.org/10.1080/23273798.2016.1217030

Garcia-Romeu, A., Davis, A. K., Erowid, F., Erowid, E., Griffiths, R. R., & Johnson, M. W. (2019). Cessation and reduction in alcohol consumption and misuse after psychedelic use. Journal of Psychopharmacology, 33(9), 1088–1101. https://doi.org/10.1177/0269881119845793

Vollenweider, F. X. [Horizons]. (April 27, 2010). Neuronal Network and Neurotransmitter Dynamics Underlying Psychedelic-Induced Altered States of Consciousness in Humans [Video File]. Retrieved from https://vimeo.com/11258033

Preller, K. H., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., StΓ€mpfli, P., ...Vollenweider, F. X. (2017). The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Current Biology, 27(3), 451–457. https://doi.org/ 10.1016/j.cub.2016.12.030

Kraehenmann, R., Pokorny, D., Aicher, H., Preller, K. H., Pokorny, T., Bosch, O. G., ...Vollenweider, F. X. (2017b). LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation. Frontiers in Pharmacology, 8, 814. https://doi.org/10.3389/fphar.2017.00814

Hofstadter, D. R. (2007). Analogy as the Core of Cognition. In D. Gentner, K. J. Holyoak, & B. N. Kokinov (Eds.) The analogical mind: perspectives from cognitive science. Cambridge, MA: The MIT Press.

Moore, H. G., (2009). Plato’s analogical thought. College of Liberal Arts & Social Sciences Theses and Dissertations, 7.

Sunstein, C. R. (1993). On Analogical Reasoning. Harvard Law Review, 106(3), 741. https://doi.org/10.2307/1341662

Spitzer, M., Thimm, M., Hermle, L., Holzmann, P., Kovar, K.-A., Heimann, H., et al. (1996). Increased activation of indirect semantic associations under psilocybin. Biol. Psychiatry 39, 1055–1057. https://doi.org/10.1016/0006-3223(95)00418-1

Dahl, D. W., & Moreau, P. (2002). The Influence and Value of Analogical Thinking during New Product Ideation. Journal of Marketing Research, 39(1), 47–60. https://doi.org/10.2307/1558583

Lewis, C. R., Preller, K. H., Kraehenmann, R., Michels, L., Staempfli, P., & Vollenweider, F. X. (2017). Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow. NeuroImage, 159, 70–78. https://doi.org/10.1016/j.neuroimage.2017.07.020

Bonner, M. F., Price, A. R., Peelle, J. E., & Grossman, M. (2016). Semantics of the Visual Environment Encoded in Parahippocampal Cortex. Journal of Cognitive Neuroscience, 28(3), 361–378. https://doi.org/10.1162/jocn_a_00908

Binder, J. R., & Desai, R. H. (2011). The neurobiology of semantic memory. Trends in Cognitive Sciences, 15(11), 527–536. https://doi.org/10.1016/j.tics.2011.10.001

Kaelen, M., Roseman, L., Kahan, J., Santos-Ribeiro, A., Orban, C., Lorenz, R., ...Carhart-Harris, R. (2016). LSD modulates music-induced imagery via changes in parahippocampal connectivity. European Neuropsychopharmacology, 26(7), 1099–1109. https://doi.org/10.1016/j.euroneuro.2016.03.018

Bressloff, P. C., Cowan, J. D., Golubitsky, M., Thomas, P. J., & Wiener, M. C. (2001). Geometric visual hallucinations, Euclidean symmetry and the functional architecture of striate cortex. Philosophical Transactions of the Royal Society of London. Series B, 356(1407), 299. https://doi.org/10.1098/rstb.2000.0769

Gu Q. (2007) Serotonin Involvement in Plasticity of the Visual Cortex. In Tseng KY., Atzori M. (Eds.) Monoaminergic Modulation of Cortical Excitability. Boston, MA: Springer.

Geyer, M. A., & Vollenweider, F. X. (2008). Serotonin research: contributions to understanding psychoses. Trends in Pharmacological Sciences, 29(9), 445–453. https://doi.org/10.1016/j.tips.2008.06.006

Preller, K. H., Razi, A., Zeidman, P., StΓ€mpfli, P., Friston, K. J., & Vollenweider, F. X. (2019). Effective connectivity changes in LSD-induced altered states of consciousness in humans. Proceedings of the National Academy of Sciences, 116(7), 2743–2748. https://doi.org/ 10.1073/pnas.1815129116

Jung, C. G., (1976). C. G. Jung: Letters. - Volume 2: 1951-1961. Routledge.

Carhart-Harris, R. L., Erritzoe, D., Haijen, E., Kaelen, M., & Watts, R. (2017). Psychedelics and connectedness. Psychopharmacology, 235(2), 547–550. https://doi.org/10.1007/s00213-017-4701-y

Griffiths, R. R., Johnson, M. W., Richards, W. A., Richards, B. D., McCann, U., & Jesse, R. (2011). Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology, 218(4), 649–665. https://doi.org/10.1007/s00213-011-2358-5

Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., Theunissen, E. L., Holze, F., Liechti, M. E., ...Kuypers, K. P. C. (2020). Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers. ACS Pharmacology & Translational Science, 2020. https://doi.org/10.1021/acsptsci.0c00099

Belser, A. B., Agin-Liebes, G., Swift, T. C., Terrana, S., Devenot, N., Friedman, H. L., ...Ross, S. (2017). Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological Analysis. Journal of Humanistic Psychology, 57(4), 354–388. https://doi.org/10.1177/0022167817706884

Johnson, M. W., Garcia-Romeu, A., Griffiths, R. R. (2017). Long-term follow-up of psilocybin-facilitated smoking cessation. The American Journal of Drug and Alcohol Abuse, 43, 55-60. https://doi.org/10.3109/00952990.2016.1170135

Griffiths, R.R., Johnson, M.W., Richards, W.A., Richards, B.D., Jesse, R., MacLean, K.A., Barrett, F.S., Cosimano, M.P., Klinedinst, M.A. (2018). Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors. J. Psychopharmacol, 32 (1), 49-69. https://doi.org/10.1177/0269881117731279